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Recombinant G-Protein-Coupled Receptors as Screening Tools for
| Content Provider | Scilit |
|---|---|
| Author | Strosberg, A. Donny Fernandes, Prabhavathi B. |
| Copyright Year | 1998 |
| Description | Membrane receptors may be studied both by ligand-binding and by effector triggering. Assays to identify agonists or antagonists make use of both properties. Initial, high-throughput screening may be used to screen large combinatorial libraries of synthetic or natural compounds to identify "lead" candidates. Once purified, these leads may be assayed in second-messenger assays to differentiate agonists from antagonists. Book Name: Receptor - Based Drug Design |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2010-0-27297-3&isbn=9780429121326&doi=10.1201/9781420001136-39&format=pdf |
| Ending Page | 380 |
| Page Count | 18 |
| Starting Page | 363 |
| DOI | 10.1201/9781420001136-39 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1998-04-10 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Receptor - Based Drug Design Biochemistry and Molecular Biology Medicinal Chemistry Protein Throughput Libraries Messenger Combinatorial Recombinant Candidates Compounds Differentiate Purified |
| Content Type | Text |
| Resource Type | Chapter |
