Optimized Henry Reaction Conditions for the Synthesis of an l-Fucose C-Glycosyl Derivative

Content Provider	Scilit
Author	Hauck, D. Jumde, V. R. Crawford, C. J. Titz, A.
Copyright Year	2021
Description	18 C-Glycosyl compounds are found in many natural products and are also often introduced into synthetic glycoconjugates to increase stability toward acid hydrolysis and glycosidase degradation of their parent $O-glycosides.^{ 1 }$ d-Mannose- and l-fucose-derived C-glycosyl substances have been developed as potent inhibitors of the bacterial lectin $LecB.^{ 2,3 }$ Their synthesis starts with a Henry addition/condensation sequence of nitromethane with l-fucose, followed by reduction of the nitro group and further derivatization. Book Name: Carbohydrate Chemistry
Related Links	https://content.taylorfrancis.com/books/download?dac=C2017-0-61636-7&isbn=9781351256087&format=googlePreviewPdf
Ending Page	22
Page Count	6
Starting Page	17
DOI	10.1201/9781351256087-3
Language	English
Publisher	Informa UK Limited
Publisher Date	2021-01-14
Access Restriction	Open
Subject Keyword	Book Name: Carbohydrate Chemistry Organic Chemistry Optimized Fucose Glycosyl Glycoconjugates Addition/condensation Glycosidase Lectin Derivatization
Content Type	Text
Resource Type	Chapter