NDLI: The anti-CD80 primatized monoclonal antibody, galiximab, is well-tolerated but has limited activity in relapsed Hodgkin lymphoma: Cancer and Leukemia Group B 50602 (Alliance)

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The anti-CD80 primatized monoclonal antibody, galiximab, is well-tolerated but has limited activity in relapsed Hodgkin lymphoma: Cancer and Leukemia Group B 50602 (Alliance)

Content Provider	Scilit
Author	Smith, Sonali M. Schöder, Heiko Johnson, Jeffrey L. Jung, Sin-Ho Bartlett, Nancy Cheson, Bruce D.
Copyright Year	2013
Description	Relapsed Hodgkin lymphoma remains a clinical challenge, with few non-cytotoxic treatment options. CD80 is a surface antigen that normally functions as a co-stimulatory molecule but is aberrantly and uniformly expressed on Reed–Sternberg cells. Galiximab is a primatized monoclonal antibody against CD80, with a favorable toxicity profile demonstrated in other lymphomas. Cancer and Leukemia Group B (CALGB) 50602 (Alliance) tested single-agent galiximab in a highly refractory group of patients with Hodgkin lymphoma (median 3 prior regimens, 83% failing after prior stem cell transplant) to determine the efficacy. The overall response rate was 10.3% and the median progression-free survival was 1.6 months. Galiximab was well-tolerated, with minimal grade 3 or 4 toxicities. Despite this preclinical rationale, single-agent galiximab had limited activity in heavily pretreated Hodgkin lymphoma.
Related Links	http://europepmc.org/articles/pmc5499151?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499151/pdf https://www.tandfonline.com/doi/pdf/10.3109/10428194.2012.744453
Ending Page	1410
Page Count	6
Starting Page	1405
ISSN	10428194
e-ISSN	10292403
DOI	10.3109/10428194.2012.744453
Journal	Leukemia & Lymphoma
Issue Number	7
Volume Number	54
Language	English
Publisher	Informa UK Limited
Publisher Date	2013-07-01
Access Restriction	Open
Subject Keyword	Hematology Hodgkin Lymphoma Galiximab Clinical Trial
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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