Interactions of engineered nanomaterials in physiological media and implications forin vitrodosimetry

Content Provider	Scilit
Author	Cohen, Joel DeLoid, Glen Pyrgiotakis, Georgios Demokritou, Philip
Copyright Year	2012
Description	In vitro toxicity assays are efficient and inexpensive tools for screening the increasing number of engineered nanomaterials (ENMs) entering the consumer market. However, the data produced by in vitro studies often vary substantially among different studies and from in vivo data. In part, these discrepancies may be attributable to lack of standardisation in dispersion protocols and inadequate characterisation of particle–media interactions which may affect the particle kinetics and the dose delivered to cells. In this study, a novel approach for preparation of monodisperse, stabilised liquid suspensions is presented and coupled with a numerical model which estimates delivered dose values. Empirically derived material- and media-specific functions are presented for each media–ENM system that can be used to convert administered doses to delivered doses. The interactions of ENMs with a variety of physiologic media were investigated and the importance of this approach was demonstrated by in vitro cytotoxicity assays using THP-1 macrophages.
Related Links	http://europepmc.org/articles/pmc4479135?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479135/pdf https://www.tandfonline.com/doi/pdf/10.3109/17435390.2012.666576
Ending Page	431
Page Count	15
Starting Page	417
ISSN	17435390
e-ISSN	17435404
DOI	10.3109/17435390.2012.666576
Journal	Nanotoxicology
Issue Number	4
Volume Number	7
Language	English
Publisher	Informa UK Limited
Publisher Date	2012-03-20
Access Restriction	Open
Subject Keyword	Pharmacology and Pharmacy Nanotoxicology Liquid Suspension Dosimetry
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Toxicology Biomedical Engineering