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A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor
| Content Provider | Scilit |
|---|---|
| Author | Chen, Hang Zhao, Xiaoqian Xi, Zhong Zhang, Ye Li, Hang Li, Zengyao Shi, Haoze Huang, Longchang Shen, Renhui Tao, Jianxin Wang, Tong |
| Copyright Year | 2019 |
| Description | Background: A silicon nanowire field effect transistor biosensor has four advantages in the detection of small biomolecules. It is mark-free, immediately responsive, highly sensitive, and specific. However, because of environments with a high salt concentration, the Debye screening effect has been a major issue in biological detection. Objective: To overcome Debye screening effect, realize the clinical application of silicon nanowire field effect transistor and verify its specificity and sensitivity. Materials and methods: The test solution was desalted by miniature blood dialyzer, and then the tumor markers were detected by silicon nanowire field effect transistor. Results: Tumor markers in serum were detected successfully and their sensitivity and specificity were verified. Conclusion: This method was found to effectively promote the development of semiconductor materials in biological solution detection. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505467/pdf https://www.dovepress.com/getfile.php?fileID=49459 |
| Ending Page | 2993 |
| Page Count | 9 |
| Starting Page | 2985 |
| e-ISSN | 11782013 |
| DOI | 10.2147/ijn.s198734 |
| Journal | International Journal of Nanomedicine |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-04-01 |
| Access Restriction | Open |
| Subject Keyword | Instrumentation Debye Screening Effect Biosensor Dialysis Silicon Nanowire Tumor Marker |
| Content Type | Text |
| Resource Type | Article |
