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REST/ACTIVITY RHYTHMS AND MORTALITY RATES IN OLDER MEN: MROS SLEEP STUDY
| Content Provider | Scilit |
|---|---|
| Author | Paudel, Misti L. Taylor, Brent C. Ancoli-Israel, Sonia Blackwell, Terri Stone, Katie L. Tranah, Greg Redline, Susan Cummings, Steven R. Ensrud, Kristine |
| Copyright Year | 2010 |
| Description | An association between increased risk of mortality and disruptions in rest/activity circadian rhythms (RAR) has been shown among adults with dementia and with metastatic colorectal cancer. However, the association among a more general population of older adults has not been studied. Our study population consisted of 2964 men aged ≥ 67 yrs of age enrolled in the Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study. Rest/activity patterns were measured with wrist actigraphy. RAR parameters were computed and expressed as quintiles, and included acrophase (time of peak activity level), amplitude (peak-to-nadir difference), mesor (middle of the peak), pseudo F-value (overall circadian rhythmicity), beta (steepness), and alpha (peak-to-trough width). After adjustment for multiple potential confounders, men in the lowest quintile of pseudo F-value had a 57% higher mortality rate (hazard ratio [HR] = 1.57, 95% CI, 1.03–2.39) than men in the highest quintile. This association was even stronger with increased risk of cardiovascular disease-related mortality (CVD) (HR = 2.32, 95% CI, 1.04–5.22). Additionally, men in the lowest quintile of acrophase had a 2.8-fold higher rate of CVD-related mortality (HR = 2.84, 95% CI, 1.29–6.24). There was no evidence of independent associations with amplitude, mesor, alpha, beta, and mortality risk. Older men with less robust RAR and earlier acrophase timing have modestly higher all-cause and CVD-related mortality rates. Further research should examine potential biological mechanisms underlying this association. (Author correspondence: ames0047@umn.edu) |
| Related Links | http://europepmc.org/articles/pmc2918381?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918381/pdf https://www.tandfonline.com/doi/pdf/10.3109/07420520903419157 |
| Ending Page | 377 |
| Page Count | 15 |
| Starting Page | 363 |
| ISSN | 07420528 |
| e-ISSN | 15256073 |
| DOI | 10.3109/07420520903419157 |
| Journal | Chronobiology international |
| Issue Number | 2 |
| Volume Number | 27 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-03-01 |
| Access Restriction | Open |
| Subject Keyword | Peripheral Vascular Disease Rest/activity Rhythms Circadian Rhythms Mortality Elderly |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) |
