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Sgo1 is required for co-segregation of sister chromatids during achiasmate meiosis I
| Content Provider | Scilit |
|---|---|
| Author | Dudas, Andrej Ahmad, Shazia Gregan, Juraj |
| Copyright Year | 2011 |
| Description | The reduction of chromosome number during meiosis is achieved by two successive rounds of chromosome segregation, called meiosis I and meiosis II. While meiosis II is similar to mitosis in that sister kinetochores are bi-oriented and segregate to opposite poles, recombined homologous chromosomes segregate during the first meiotic division. Formation of chiasmata, mono-orientation of sister kinetochores and protection of centromeric cohesion are three major features of meiosis I chromosomes which ensure the reductional nature of chromosome segregation. Here we show that sister chromatids frequently segregate to opposite poles during meiosis I in fission yeast cells that lack both chiasmata and the protector of centromeric cohesion Sgo1. Our data are consistent with the notion that sister kinetochores are frequently bi-oriented in the absence of chiasmata and that Sgo1 prevents equational segregation of sister chromatids during achiasmate meiosis I. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cc.10.6.15032?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100875/pdf |
| Ending Page | 955 |
| Page Count | 5 |
| Starting Page | 951 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.4161/cc.10.6.15032 |
| Journal | Cell Cycle |
| Issue Number | 6 |
| Volume Number | 10 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2011-03-15 |
| Access Restriction | Open |
| Subject Keyword | Cell Biology Meiosis Chromosome Segregation Recombination Kinetochore Fission Yeast |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
