NDLI: Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

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Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

Content Provider	Scilit
Author	Zhang, Chengwei Zhao, Xiaozhi Guo, Suhan Lin, Tingsheng Guo, Hongqian
Copyright Year	2017
Description	Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles Chengwei Zhang,1 Xiaozhi Zhao,1 Suhan Guo,2 Tingsheng Lin,1 Hongqian Guo1 1Department of Urology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, 2School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China Dopamine is a neurotransmitter commonly used in clinical treatment. Polydopamine (PDA) has excellent histocompatibility and biosafety and can efficiently convert near-infrared reflection (NIR) to thermal energy. In this study, PDA was used as a promising carrier, and pH-responsive polymer-coated drug-loaded PDA nanoparticles (NPs; doxorubicin@poly(allylamine)-citraconic anhydride [Dox@PAH-cit]/PDA NPs) were developed. As expected, the Dox@PAH-cit/PDA NPs exhibited excellent photothermal efficiency. In addition, at a low pH condition, the loaded Dox was released from the NPs due to the amide hydrolysis of PAH-cit. Upon NIR exposure (808 nm), the temperature of the NP solution rapidly increases to kill tumor cells. Compared with unbound chemotherapy drugs, the NPs have a stronger cell uptake ability. In vivo, the PDA NPs were able to efficiently accumulate at the tumor location. After intravenous administration and NIR exposure, tumor growth was significantly inhibited. In summary, the present investigation demonstrated that the Dox@PAH-cit/PDA NPs presented highly effective photothermal chemotherapy for prostate cancer. Keywords: prostate cancer, photothermal therapy, near-infrared reflection, dopamine, PAH-cit, drug delivery
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348077/pdf https://www.dovepress.com/getfile.php?fileID=35336
Ending Page	1840
Page Count	14
Starting Page	1827
e-ISSN	11782013
DOI	10.2147/ijn.s130539
Journal	International Journal of Nanomedicine
Volume Number	12
Language	English
Publisher	Informa UK Limited
Publisher Date	2017-03-01
Access Restriction	Open
Subject Keyword	Biomaterials Pah-cit Dopamine Drug Delivery Near-infrared Reflection Photothermal Therapy Prostate Cancer
Content Type	Text
Resource Type	Article

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