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Sequential Designs and Methods—Part I: Expected Sample Size and Two-Stage Phase II Trials in Oncology
| Content Provider | Scilit |
|---|---|
| Author | Shih, Weichung Joe Aisner, Joseph |
| Copyright Year | 2015 |
| Description | In Chapter 4, we mainly considered the fixed sample size design, in which there is no interim analysis. As we alluded to in Chapter 1, however, clinical trials often require periodic monitoring and data analyses at interim stages, while patients are continuously enrolled. This monitoring and analysis is especially necessary for trials that involve life-threatening diseases, potentially toxic therapies, long-term follow-ups, or large sample sizes. In this chapter and in Chapter 7, we examine sequential designs and methods for clinical trials with interim stages, with an illustration using oncology trials. Book Name: Statistical Design and Analysis of Clinical Trials |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2014-0-29059-9&isbn=9780429095009&doi=10.1201/b18752-10&format=pdf |
| Ending Page | 145 |
| Page Count | 12 |
| Starting Page | 134 |
| DOI | 10.1201/b18752-10 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-07-28 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Statistical Design and Analysis of Clinical Trials Sample Size Oncology Trials Sequential Designs Designs and Methods Interim Stages |
| Content Type | Text |
| Resource Type | Chapter |
