NDLI: Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes

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Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes

Content Provider	Scilit
Author	Kontoghiorghes, George J. Kontoghiorghe, Christina N.
Copyright Year	2016
Description	Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes Christina N Kontoghiorghe, George J Kontoghiorghes Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, Cyprus The birth rate of thalassemia, which is endemic in Southeast Asia, the Middle East, and the Mediterranean, exceeds 100,000 per year. There are many genetic variants in thalassemia with different pathological severity, ranging from a mild and asymptomatic anemia to life-threatening clinical effects, requiring lifelong treatment, such as regular transfusions in thalassemia major (TM). Some of the thalassemias are non-transfusion-dependent, including many thalassemia intermedia (TI) variants, where iron overload is caused by chronic increase in iron absorption due to ineffective erythropoiesis. Many TI patients receive occasional transfusions. The rate of iron overloading in TI is much slower in comparison to TM patients. Iron toxicity in TI is usually manifested by the age of 30â
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745840/pdf https://www.dovepress.com/getfile.php?fileID=28862
Ending Page	481
Page Count	17
Starting Page	465
e-ISSN	11778881
DOI	10.2147/dddt.s79458
Journal	Drug design, development and therapy
Volume Number	10
Language	English
Publisher	Informa UK Limited
Publisher Date	2016-01-01
Access Restriction	Open
Subject Keyword	Hematology Chelation Therapy Deferasirox Deferiprone Deferoxamine Efficacy Iron Absorption Iron Overload Safety Thalassemia Intermedia
Content Type	Text
Resource Type	Article

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