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The role of 18F-FDG PET/CT imaging in patient with malignant PEComa treated with mTOR inhibitor

Content Provider	Scilit
Author	Sun, Xiaorong Sun, Lu Xing, Ligang Li, Yuhui
Copyright Year	2015
Description	The role of 18F-FDG PET/CT imaging in patient with malignant PEComa treated with mTOR inhibitor Lu Sun,1 Xiaorong Sun,2 Yuhui Li,3 Ligang Xing4 1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, 2PET/CT Center, Department of Radiology, 3Department of Pathology, 4Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, People's Republic of China Malignant perivascular epithelioid cell tumor (malignant PEComa) is a rare disease for which the diagnostic criteria and treatment options have not been established. Since PEComa is associated with upregulation of mammalian target of rapamycin (mTOR) pathway which controls Glut-1 (glucose transporter) function, increased 18F-fluorodeoxyglucose (18F-FDG) uptake may indicate the over activation of mTOR pathway and may guide selectively inhibiting mTOR pathway treatment. We report a malignant PEComa patient who presented for 18F-FDG positron emission tomography/computed tomography (PET/CT) restaging. The tumor had shown significant avidity on PET/CT as well as an evident response to sirolimus (rapamycin, Rapamune™) that supports the utility of mTOR inhibitors as an effective treatment for malignant PEComa. Therefore, 18F-FDG PET/CT is helpful in restaging and guiding treatment for malignant PEComa with mTOR inhibitors. Keywords: malignant perivascular epithelioid cell tumor, PEComa, mTOR inhibitor, FDG, PET/CT
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525788/pdf https://www.dovepress.com/getfile.php?fileID=26234
Ending Page	1970
Page Count	4
Starting Page	1967
ISSN	11786930
DOI	10.2147/ott.s85444
Journal	OncoTargets and therapy
Volume Number	8
Language	English
Publisher	Informa UK Limited
Publisher Date	2015-07-01
Access Restriction	Open
Subject Keyword	Agricultural Engineering Malignant Perivascular Epithelioid Cell Tumor Pecoma Mtor Inhibitor Pet/ct
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Oncology

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