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CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy
| Content Provider | Scilit |
|---|---|
| Author | Chen, Nan Morello, Aurore Tano, Zachary Adusumilli, Prasad S. |
| Copyright Year | 2017 |
| Description | PD-L1/2 expression in solid tumors inhibits chimeric antigen receptor (CAR) T-cell efficacy. A PD-1 dominant negative receptor expressed in CAR T cells provides cell-intrinsic checkpoint blockade and augments antitumor efficacy. A combinatorial immunotherapeutic strategy of combining CAR T cells with checkpoint blockade is a promising treatment approach for solid tumors. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2016.1273302?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353939/pdf |
| e-ISSN | 2162402X |
| DOI | 10.1080/2162402x.2016.1273302 |
| Journal | OncoImmunology |
| Issue Number | 2 |
| Volume Number | 6 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2017-02-01 |
| Access Restriction | Open |
| Subject Keyword | Research and Experimental Medicine Adoptive T-cell Therapy Breast Cancer Immunosuppression Lung Cancer Mesothelioma Pd-1 Blockade Tumor Microenvironment |
| Content Type | Text |
| Resource Type | Article |
