NDLI: Leptospiraseropositivity as a risk factor for Mesoamerican Nephropathy

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Leptospiraseropositivity as a risk factor for Mesoamerican Nephropathy

Content Provider	Scilit
Author	Riefkohl, Alejandro Ramírez-Rubio, Oriana Laws, Rebecca L. McClean, Michael D. Weiner, Daniel E. Kaufman, James S. Galloway, Renee L. Shadomy, Sean V. Guerra, Marta Amador, Juan José Sánchez, José Marcel López-Pilarte, Damaris Parikh, Chirag R. Leibler, Jessica H. Brooks, Daniel R.
Copyright Year	2017
Description	Background: Leptospirosis is postulated as a possible cause of Mesoamerican Nephropathy (MeN) in Central American workers. Objectives: Investigate job-specific Leptospira seroprevalence and its association with kidney disease biomarkers. Methods: In 282 sugarcane workers, 47 sugarcane applicants and 160 workers in other industries, we measured anti-leptospiral antibodies, serum creatinine, and urinary injury biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and N-acetyl-D-glucosaminidase (NAG). Results: Leptospira seroprevalence differed among job categories and was highest among sugarcane cutters (59%). Seropositive sugarcane workers had higher NGAL concentrations (relative mean: 1.28; 95% CI: 0.94–1.75) compared to those who were seronegative, with similar findings among field and non-field workers. Conclusions: Leptospira seroprevalence varied by job category. There was some indication that seropositivity was associated with elevated biomarker levels, but results were inconsistent. Additional studies may help establish whether Leptospira infection plays any role in MeN among Central American workers.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060841/pdf
ISSN	10773525
e-ISSN	20493967
DOI	10.1080/10773525.2016.1275462
Journal	International journal of occupational and environmental health
Issue Number	1
Volume Number	23
Language	English
Publisher	Informa UK Limited
Publisher Date	2017-01-02
Access Restriction	Open
Subject Keyword	Medical Laboratory Technology Chronic Kidney Disease (ckd) Mesoamerican Nephropathy (men) Chronic Kidney Disease of Nontraditional Etiology (ckdnt) Leptospira Ieptospirosis Neutrophil Gelatinase-associated Lipocalin (ngal) Interleukin-18 (il-18) N-acetyl-d- Glucosaminidase (nag)
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

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