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UDP Facilitates Microglial Phagocytosis Through P2Y6 Receptors
| Content Provider | Scilit |
|---|---|
| Author | Inoue, Kazuhide |
| Copyright Year | 2007 |
| Description | Microglia engage in the clearance of dead cells or dangerous debris. When neighboring cells are injured, the cells release or leak ATP into extracellular space and microglia rapidly move toward or extend a process to the nucleotides as chemotaxis through P2Y12 receptors. In the meanwhile, microglia express the metabotropic P2Y6 receptors, the activation of which by uridine 5'-diphosphate (UDP) triggers microglial phagocytosis in a concentration-dependent fashion. UDP/UTP was leaked when hippocampal neurons were damaged by kainic acid in vivo and in vitro. Systemic administration of kainic acid in rats resulted in neuronal cell death in the hippocampal CA1 and CA3 regions, where increases in mRNA for P2Y6 receptors in activated microglia. Thus, the P2Y6 receptor is upregulated when neurons are damaged, and would function as a sensor for phagocytosis by sensing diffusible UDP signals. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.4161/cam.1.3.4937?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634013/pdf |
| Ending Page | 132 |
| Page Count | 2 |
| Starting Page | 131 |
| ISSN | 19336918 |
| e-ISSN | 19336926 |
| DOI | 10.4161/cam.1.3.4937 |
| Journal | Cell adhesion & migration |
| Issue Number | 3 |
| Volume Number | 1 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2007-07-01 |
| Access Restriction | Open |
| Subject Keyword | Cell Biology Neurosciences Cell Death Function Phagocytosis Microglia Hippocampal P2y6 Receptors Kainic |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Cellular and Molecular Neuroscience |
