NDLI: MiR-202-5p/PTEN mediates doxorubicin-resistance of breast cancer cells via PI3K/Akt signaling pathway

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MiR-202-5p/PTEN mediates doxorubicin-resistance of breast cancer cells via PI3K/Akt signaling pathway

Content Provider	Scilit
Author	Liu, Tao Guo, Jichao Zhang, Xiaoxia
Copyright Year	2019
Description	We intended to explore the effect of miR-202-5p and phosphatase and tensin homolog (PTEN) on doxorubicin (DOX) resistance of breast cancer cells. The result of quantitative reverse transcription-polymerase chain reaction (qRT-PCR) reveals that miR-202-5p was highly expressed in drug-resistant breast cancer tissues, while PTEN was expressed less. MiR-202-5p directly targeted PTEN. Further, it was found that the overexpression of miR-202-5p promoted the DOX resistance and proliferation as well as decreased apoptosis of MCF-7 cells. The lower expression of miR-202-5p inhibited DOX resistance and proliferation as well as increased the apoptosis of MCF-7/DOX cells. In vivo experiments showed that mice with downregulated miR-202-5p had smaller tumor volume and lower Ki67 level. The overexpression of PTEN declined the proliferation of MCF7 cells, while miR-202-5p's overexpression could offset the function of overexpression of PTEN. The knockdown of PTEN promoted MCF7/DOX cell proliferation that could be counteracted by miR-202-5p silence. Moreover, we also revealed that downregulated miR-202-5p expression inhibited PI3k/Akt signaling pathway-related protein by regulating expression of PTEN.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606016/pdf
Ending Page	998
Page Count	10
Starting Page	989
ISSN	15384047
e-ISSN	15558576
DOI	10.1080/15384047.2019.1591674
Journal	Cancer Biology & Therapy
Issue Number	7
Volume Number	20
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-03-26
Access Restriction	Open
Subject Keyword	Biochemistry and Molecular Biology Breast Cancer Mir-202-5p Pi3k/akt Doxorubicin
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pharmacology Molecular Medicine Oncology

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