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In vitroanti-inflammatory activity of spherical silver nanoparticles and monodisperse hexagonal gold nanoparticles by fruit extract ofPrunus serrulata: a green synthetic approach
| Content Provider | Scilit |
|---|---|
| Author | Singh, Priyanka Ahn, Sungeun Kang, Jong-Pyo Veronika, Soshnikova Huo, Yue Singh, Hina Chokkaligam, Mohan Farh, Mohamed El-Agamy Aceituno, Verónica Castro Kim, Yeon Ju Yang, Deok-Chun |
| Copyright Year | 2017 |
| Description | Recently, green metal nanoparticles have received global attention owing to their economical synthesis, biocompatible nature, widespread biomedical and environmental applications. Current study demonstrates a sustainable approach for the green synthesis of silver nanoparticles (P-AgNPs) and gold nanoparticles (P-AuNPs) from P. serrulata fresh fruit extract. The silver and gold nanoparticles were synthesized in a very rapid, efficient and facile manner, within 50 min and 30 s at 80 °C, respectively. The nanoparticles were characterized by using visual observation, UV–Vis, FE-TEM, EDX, elemental mapping, FT-IR, XRD and DLS, which confirmed the formation of monodispersed, crystalline and stable nanoparticles. Further, we explored these nanoparticles for anti-inflammatory activity through inhibition of downstream NF-κB activation in macrophages (RAW264.7). We demonstrated that the nanoparticles reduced expression of inflammatory mediators such as nitric oxide (NO), prostaglandin E2 $(PEG_{2}$), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) was attenuated in lipopolysaccharide (LPS)-induced RAW264.7 cells. Furthermore, nanoparticles significantly suppressed LPS-induced activation of NF-κB signalling pathway via p38 MAPK in RAW 264.7 cells. To the best of our knowledge, this is the first report on the efficient green synthesis of P-AgNPs and P-AuNPs using P. serrulata fresh fruit extract and its in vitro anti-inflammatory effects. Collectively, our results suggest that P. serrulata fresh fruit extract is a green resource for the eco-friendly synthesis of P-AgNPs and P-AuNPs, which further can be utilized as a novel therapeutic agent for prevention and cure of inflammation due to their biocompatible nature. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/21691401.2017.1408117?needAccess=true |
| ISSN | 21691401 |
| e-ISSN | 2169141X |
| DOI | 10.1080/21691401.2017.1408117 |
| Journal | Artificial cells, nanomedicine, and biotechnology |
| Issue Number | 8 |
| Volume Number | 46 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2017-11-30 |
| Access Restriction | Open |
| Subject Keyword | Literary Studies Green Synthesis P. Serrulata Silver Nanoparticles Gold Nanoparticles Inflammation Nf-κb |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biomedical Engineering Biotechnology Pharmaceutical Science |
