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The Protective Effect of Ebselen on Radiocontrast-Induced Nephrotoxicity
| Content Provider | Scilit |
|---|---|
| Author | Ozgur, Tumay Tutanc, Murat Zararsiz, Ismail Motor, Sedat Ozturk, Oktay Hasan Yaldiz, Mehmet Kurtgoz, Ozgur Yildirim |
| Copyright Year | 2012 |
| Description | Aim: Radiocontrast-induced nephropathy has become one of the most important causes of renal acute failure. The most effective management of reducing the incidence of contrast nephropathy is to understand and prevent its causes. We aimed to investigate the protective role of ebselen against radiocontrast-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Methods: Albino Wistar rats were randomly separated into four groups. The Group 1 rats were treated with sodium chloride as the control group, Group 2 with radiocontrast, Group 3 with radiocontrast plus ebselen, and Group 4 with ebselen alone. After 24 h, the animals over the experimental period were euthanized and blood samples were analyzed for blood urea nitrogen (BUN) and serum creatinine (Cr) levels. Kidney sections were analyzed for malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as histopathological changes. Results: In the radiocontrast group, BUN, MDA, and GSH-Px levels increased while SOD activity decreased compared with the control group. These decays were improved by ebselen administration in the radiocontrast group. Significant histological deteriorations were observed in the radiocontrast group. We noted improvement in the histologic findings with ebselen administration. Conclusion: These results indicate that ebselen might produce a protective mechanism against radiocontrast-induced nephrotoxicity. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/0886022X.2012.706880?needAccess=true |
| Ending Page | 997 |
| Page Count | 7 |
| Starting Page | 991 |
| ISSN | 0886022X |
| e-ISSN | 15256049 |
| DOI | 10.3109/0886022x.2012.706880 |
| Journal | Renal Failure |
| Issue Number | 8 |
| Volume Number | 34 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2012-07-26 |
| Access Restriction | Open |
| Subject Keyword | Integrative and Complementary Medicine Toxicology Radiocontrast Ebselen Nephrotoxicity Protective Effect |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine Nephrology |
