NDLI: Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Please wait, while we are loading the content...

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Content Provider	Scilit
Author	Thomas, Rachael Seiser, Eric L. Motsinger-Reif, Alison Borst, Luke Valli, Victor E. Kelley, Kathryn Suter, Steven E. Argyle, David Burgess, Kristine Bell, Jerold Lindblad-Toh, Kerstin Modiano, Jaime F. Breen, Matthew
Copyright Year	2011
Description	Identification of the genomic regions most intimately associated with non-Hodgkin lymphoma (NHL) pathogenesis is confounded by the genetic heterogeneity of human populations. We hypothesize that the restricted genetic variation of purebred dogs, combined with the contrasting architecture of the human and canine karyotypes, will increase the penetrance of fundamental NHL-associated chromosomal aberrations in both species. We surveyed non-random aneuploidy in 150 canine NHL cases, revealing limited genomic instability compared to their human counterparts and no evidence for CDKN2A/B deletion in canine B-cell NHL. 'Genomic recoding' of canine NHL data into a 'virtual human' chromosome format showed remarkably few regions of copy number aberration (CNA) shared between both species, restricted to regions of dog chromosomes 13 and 31, and human chromosomes 8 and 21. Our data suggest that gene discovery in NHL may be enhanced through comparative studies exploiting the less complex association between CNAs and tumor pathogenesis in canine patients.
Related Links	http://europepmc.org/articles/pmc4304668?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304668/pdf https://www.tandfonline.com/doi/pdf/10.3109/10428194.2011.559802
Ending Page	1335
Page Count	15
Starting Page	1321
ISSN	10428194
e-ISSN	10292403
DOI	10.3109/10428194.2011.559802
Journal	Leukemia & Lymphoma
Issue Number	7
Volume Number	52
Language	English
Publisher	Informa UK Limited
Publisher Date	2011-03-07
Access Restriction	Open
Subject Keyword	Hematology Comparative Genomic Hybridization (cgh) Canine Lymphoma Chromosome Microarray
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin's lymphomas

Chromosome aberrations in canine multicentric lymphomas detected with comparative genomic hybridisation and a panel of single locus probes.

Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas

DNA copy number changes in breast cancer samples using array-CGH profiling

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

Genomic abnormalities of Waldenström macroglobulinemia and related low-grade B-cell lymphomas.

Construction of a 2-mb resolution bac microarray for cgh analysis of canine tumors.

Interpretation of copy number alterations identified through clinical microarray-comparative genomic hybridization.

DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Similar Documents

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin's lymphomas

Chromosome aberrations in canine multicentric lymphomas detected with comparative genomic hybridisation and a panel of single locus probes.

Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas

DNA copy number changes in breast cancer samples using array-CGH profiling

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

Genomic abnormalities of Waldenström macroglobulinemia and related low-grade B-cell lymphomas.

Construction of a 2-mb resolution bac microarray for cgh analysis of canine tumors.

Interpretation of copy number alterations identified through clinical microarray-comparative genomic hybridization.

DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas