NDLI: Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis

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Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis

Content Provider	Scilit
Author	Wang, Bao-Long Zhang, Chang-Wen Wang, Liang Tang, Kun-Long Tanaka, Naoki Gonzalez, Frank J. Xu, Yong Fang, Zhong-Ze
Copyright Year	2018
Description	Ultra-performance liquid chromatography coupled with electrospray ionization quadrupole mass spectrometry (UPLC-ESI-QTOF MS)-based lipidomics was employed to elucidate new mechanism of alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis in mice.Multiple lipid components significantly increased in ANIT-induced intrahepatic cholestasis, including PC 16:0, 20:4, PC 16:0, 22:6, PC 16:0, 18:2, LPC 18:2, PC 18:2, LPC 18:1, PC 18:1, 14:0, SM 18:1, 16:0, oleoylcarnitine and palmitoylcarnitine. This alteration of lipid profile was induced by the changed expression of genes choline kinase (Chk) a, sphingomyelin phosphodiesterase (SMPD) and stearoylcoenzyme A desaturase 1 (SCD1).Knockout of aryl hydrocarbon receptor (Ahr) in mice can significantly reverse ANIT-induced intrahepatic cholestasis, as indicated by lowered ALT, AST and ALP activity, and liver histology. Aryl hydro-carbon receptor knockout significantly reversed ANIT-induced lipid metabolism alteration through regulating the expression of Chka.In conclusion, this study demonstrated ANIT-induced lipid metabolism disruption might be the potential pathogenesis of ANIT-induced intrahepatic cholestasis in mice.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643298/pdf
Ending Page	601
Page Count	11
Starting Page	591
ISSN	00498254
e-ISSN	13665928
DOI	10.1080/00498254.2018.1467065
Journal	Xenobiotica
Issue Number	5
Volume Number	49
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-05-04
Access Restriction	Open
Subject Keyword	Toxicology Intrahepatic Cholestasis Alpha-naphthyl Isothiocyanate (anit) Lipidomics Aryl Hydrocarbon Receptor (ahr)
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Biochemistry Toxicology Pharmacology

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