NDLI: PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy

Please wait, while we are loading the content...

PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy

Content Provider	Scilit
Author	Qiao, Yuhui Zhu, Baoling Tian, Aiju Li, Zijian
Copyright Year	2017
Description	Gold nanoparticles (AuNPs) are widely used as a drug delivery vehicle, which can accumulate in the heart through blood circulation. Therefore, it is very important to understand the effect of AuNPs on the heart, especially under pathological conditions. In this study, we found that PEG-coated AuNPs attenuate β-adrenergic receptor (β-AR)-mediated acute cardiac hypertrophy and inflammation. However, both isoproterenol, a non-selective β-AR agonist, and AuNPs did not induce cardiac function change or cardiac fibrosis. AuNPs exerted an anti-cardiac hypertrophy effect by decreasing β1-AR expression and its downstream ERK1/2 hypertrophic pathway. Our results indicated that AuNPs might be safe and have the potential to be used as multi-functional materials (drug carrier systems and anti-cardiac hypertrophy agents).
Related Links	https://www.dovepress.com/getfile.php?fileID=37226 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503492/pdf
Ending Page	4719
Page Count	11
Starting Page	4709
e-ISSN	11782013
DOI	10.2147/ijn.s130951
Journal	International Journal of Nanomedicine
Volume Number	12
Language	English
Publisher	Informa UK Limited
Publisher Date	2017-07-01
Access Restriction	Open
Subject Keyword	Biomaterials Nanotechnology Cardiac Hypertrophy Β-adrenergic Receptor Erk1/2 Signaling Pathway
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in