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Contribution of dysregulated circRNA_100876 to proliferation and metastasis of esophageal squamous cell carcinoma
| Content Provider | Scilit |
|---|---|
| Author | Cao, Sai Chen, Guohao Yan, Liumei Li, Libo Huang, Xianying |
| Copyright Year | 2018 |
| Description | Contribution of dysregulated circRNA_100876 to proliferation and metastasis of esophageal squamous cell carcinoma Sai Cao,1,* Guohao Chen,2,* Liumei Yan,3,* Libo Li,2 Xianying Huang4 1Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangdong 510515, China; 2Department of General Surgery, Dongguan People's Hospital, Dongguan 523000, China; 3Department of Gastroenterology, Wuzhou Red Cross Hospital, Wuzhou 543000, China; 4Department of Vascular Surgery, Nanfang Hospital, Southern Medical University, Guangdong 510515, China *These authors contributed equally to this work Purpose: Accumulating evidence demonstrates that circRNAs regulate diverse cellular processes and cancer progression. However, it remains unclear whether circRNAs play any functional role in esophageal squamous cell carcinoma (ESCC).Materials and methods: The significance of circRNA_100876 in ESCC was analyzed by studying circRNA_100876 expression in ESCC tissues and the association between circRNA_100876 expression and clinicopathologic parameters. The biological effects of circRNA_100876 knockdown by lentivirus-mediated siRNAs on cell proliferation, cell cycle, apoptosis, and migration were investigated in vitro and in vivo.Results: CircRNA_100876 expression was upregulated (P<0.05) and was negatively correlated with survival outcome (P<0.05) in ESCC. Inhibition of proliferation, migration, invasion, and epithelial–mesenchymal transition progression was confirmed after circRNA_100876 depletion.Conclusion: Dysregulation of circRNA_100876 expression leads to poor prognosis in ESCC by accelerating cell proliferation and metastasis. Keywords: circRNA_100876, esophageal squamous cell carcinoma, metastasis, epithelial–mesenchymal transition |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204868/pdf https://www.dovepress.com/getfile.php?fileID=45565 |
| Ending Page | 7394 |
| Page Count | 10 |
| Starting Page | 7385 |
| ISSN | 11786930 |
| DOI | 10.2147/ott.s177524 |
| Journal | OncoTargets and therapy |
| Volume Number | 11 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2018-10-01 |
| Access Restriction | Open |
| Subject Keyword | Oncology Circrna_100876 Epithelial—mesenchymal Transition Esophageal Squamous Cell Carcinoma Metastasis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Oncology |
