NDLI: Severe arthritis and tenosynovitis caused by immune checkpoint blockade therapy with pembrolizumab (anti-PD-1 antibody).

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Severe arthritis and tenosynovitis caused by immune checkpoint blockade therapy with pembrolizumab (anti-PD-1 antibody).

Content Provider	Scilit
Author	Jagpal, Aprajita Choudhary, Gagandeep Chokr, Jad
Copyright Year	2019
Description	Pembrolizumab, a monoclonal antibody against the immune checkpoint receptor-programmed cell death protein 1, has proven clinical efficacy in melanoma and other solid tumors. It increases the body's immune response against the tumor cells. However, because of an uninhibited immune system, immune-mediated adverse effects can arise. Though most adverse effects from pembrolizumab involve the gastrointestinal tract, skin, and endocrine system, rheumatologic manifestations are not very well defined. We describe two cases of severe inflammatory arthritis and tenosynovitis, which are rare adverse effects of pembrolizumab. Increased awareness of this manifestation is imperative to establish the diagnosis and initiate timely treatment.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650205/pdf
Ending Page	421
Page Count	3
Starting Page	419
ISSN	08998280
e-ISSN	15253252
DOI	10.1080/08998280.2019.1588654
Journal	Baylor University Medical Center Proceedings
Issue Number	3
Volume Number	32
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-05-14
Access Restriction	Open
Subject Keyword	Rheumatology Arthritis Checkpoint Blockade Immune Checkpoint Inhibitors Pembrolizumab
Content Type	Text
Resource Type	Article
Subject	Medicine

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