NDLI: IL-17A (-197G/A) and IL-17F (7488T/C) gene polymorphisms and cancer risk in Asian population: a meta-analysis

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IL-17A (-197G/A) and IL-17F (7488T/C) gene polymorphisms and cancer risk in Asian population: a meta-analysis

Content Provider	Scilit
Author	Dai, Wei Zhou, Qing Tan, Xuexin Sun, Changfu
Copyright Year	2014
Description	Interleukin (IL)-17 has been shown to play an important role in the pathogenesis of inflammation and cancer. The IL-17A (-197G/A) and IL-17F (7488T/C) polymorphisms have been extensively investigated with cancer risk, but individually published results have been inconclusive. The aim of this study was to clarify the effects of the IL-17A (-197G/A) and IL-17F (7488T/C) polymorphisms on cancer risk in Asian populations. Relevant studies were identified by searching databases extensively. The association between the IL-17A (-197G/A) and IL-17F (7488T/C) polymorphisms and cancer risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). A total of 12 articles with adequate information satisfied our inclusion criteria; these included 12 studies, with 4,540 cases and 5,875 controls, of IL-17A (-197G/A) polymorphism and seven studies, with 1,960 cases and 3,226 controls, of IL-17F (7488T/C) polymorphism. In the overall analysis, the IL-17A (-197G/A) polymorphism was significantly associated with increased cancer risk (P0.05), for any genetic models. Furthermore, stratification by cancer type revealed a significant correlation between the IL-17A (-197G/A) polymorphism and cancer risk for all cancer types. When stratified by source of controls, a significant correlation was observed between the IL-17A (-197G/A) polymorphism and cancer risk in the population-based control subgroup but not in hospital-based control subgroup. In conclusion, our meta-analysis provides evidence that the IL-17A (-197G/A) polymorphism might be associated with cancer risk, while no evidence suggested a significant association between IL-17F (7488T/C) polymorphism and cancer risk.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027853/pdf https://www.dovepress.com/getfile.php?fileID=20014
Ending Page	711
Page Count	9
Starting Page	703
ISSN	11786930
DOI	10.2147/ott.s62781
Journal	OncoTargets and therapy
Volume Number	7
Language	English
Publisher	Informa UK Limited
Publisher Date	2014-05-01
Access Restriction	Open
Subject Keyword	Medical Laboratory Technology Cancer Interleukin-17 Meta-analysis Polymprphism
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Oncology

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