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Clinically Meaningful Difference for the Infant Gastroesophageal Questionnaire Revised version (I-GERQ-R): A Quantitative Synthesis
| Content Provider | Scilit |
|---|---|
| Author | Smith, Adam B. Fawkes, Neil Kotze, Helen Hodgkinson, Victoria Coyle, Cathal |
| Copyright Year | 2020 |
| Description | Background: Gastroesophageal reflux disease (GORD) is a common condition affecting 30% of infants aged 0– 23 months. The Infant Gastroesophageal Questionnaire Revised version (I-GERQ-R) is an observer-reported outcome measures (ObsRO) developed to evaluate the impact of GORD on young infants. However, evidence regarding the clinically important difference (CID) for the I-GERQ-R is limited. The aim of this study was to determine a CID for the I-GERQ-R. Methods: A literature review was undertaken (PsycInfo, Embase, MedLine and EconLit databases) for longitudinal studies involving the I-GERQ-R. Articles were not limited by language or publication date. A random effects model was applied to calculate an overall CID, along with $I^{2}$ and Q statistics. Publication bias was also assessed. Results: The search identified 42 articles; 11 were selected for full-text review and 7 articles were identified for full data extraction. The studies included a total of 661 infants (range: 30 to 313); 424 infants had been diagnosed with GORD (64%). The age range of the infants across the studies was from birth to 7 months. The overall CID was − 6.54 (95% confidence interval: − 4.35 to − 8.74), Q = 17.96, p=0.08 and $I^{2}$=22.04. Conclusion: This study derived a CID for the I-GERQ-R and indicated a threshold around 6 could signify a clinically important difference for this instrument. The lower limit of the 95% confidence interval suggested a threshold of 3 to 4 could represent a minimally important difference. These results may help inform clinical decisions in evaluating meaningful change in symptom severity in children affected by GORD. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068037/pdf https://www.dovepress.com/getfile.php?fileID=56604 |
| Ending Page | 93 |
| Page Count | 7 |
| Starting Page | 87 |
| ISSN | 1179271X |
| e-ISSN | 1179271X |
| DOI | 10.2147/prom.s238673 |
| Journal | Patient related outcome measures |
| Volume Number | 11 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-03-01 |
| Access Restriction | Open |
| Subject Keyword | Nutrition and Dietetics I-gerq-r Clinically Important Difference Gastro-esophageal Reflux Disease Minimally Important Difference |
| Content Type | Text |
| Resource Type | Article |
