NDLI: Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites

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Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites

Content Provider	Scilit
Author	Martinez-Gili, Laura McDonald, Julie A. K. Liu, Zhigang Kao, Dina Allegretti, Jessica R. Monaghan, Tanya M. Barker, Grace F. Blanco, Jesús Miguéns Williams, Horace R. T. Holmes, Elaine Thursz, Mark R. Marchesi, Julian R. Mullish, Benjamin H.
Copyright Year	2020
Description	Fecal microbiota transplant (FMT) is a highly-effective therapy for recurrent Clostridioides difficile infection (rCDI), and shows promise for certain non-CDI indications. However, at present, its mechanisms of efficacy have remained poorly understood. Recent studies by our laboratory have noted the particular key importance of restoration of gut microbe-metabolite interactions in the ability of FMT to treat rCDI, including the impact of FMT upon short chain fatty acid (SCFAs) and bile acid metabolism. This includes a significant impact of these metabolites upon the life cycle of C. difficile directly, along with potential postulated additional benefits, including effects upon host immune response. In this Addendum, we first present an overview of these recent advancements in this field, and then describe additional novel data from our laboratory on the impact of FMT for rCDI upon several gut microbial-derived metabolites which had not previously been implicated as being of relevance.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524310/pdf
ISSN	19490976
e-ISSN	19490984
DOI	10.1080/19490976.2020.1810531
Journal	Gut Microbes
Issue Number	1
Volume Number	12
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-09-06
Access Restriction	Open
Subject Keyword	Biotechnology and Microbiology Gut Microbiome Metabonomics Fecal Microbiota Transplant Clostridioides Difficile Infection Bile Acids Short Chain Fatty Acids Trimethylamine
Content Type	Text
Subject	Infectious Diseases Gastroenterology Microbiology Microbiology (medical)

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