NDLI: Collective invasion of carcinoma cells

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Collective invasion of carcinoma cells

Content Provider	Scilit
Author	Gaggioli, Cedric
Copyright Year	2008
Description	Epithelial to Mesenchymal Transitions (EMT) have been suggested to be crucial during epithelial cancer cell invasion. However, in a three-dimensional “organotypic” invasion assay Squamous Cell Carcinoma (SCC) cells that retain epithelial characteristics “hitch a ride” with Carcinoma Associated Fibroblasts (CAFs) in order to collectively invade. Thus epithelial cancer cells can utilise the mesenchymal characteristics of CAFs without the need to undergo EMT themselves. This work provides new insight in cancer cell invasion and shows a new role for CAFs as a target for an anti-invasive therapy.
Related Links	https://www.tandfonline.com/doi/pdf/10.4161/cam.2.1.5705?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635002/pdf
Ending Page	47
Page Count	3
Starting Page	45
ISSN	19336918
e-ISSN	19336926
DOI	10.4161/cam.2.1.5705
Journal	Cell adhesion & migration
Issue Number	1
Volume Number	2
Language	English
Publisher	Informa UK Limited
Publisher Date	2008-01-01
Access Restriction	Open
Subject Keyword	Collective Invasion Carcinoma Associated Fibroblast Extracellular Matrix Matrix Metalloproteinases
Content Type	Text
Resource Type	Article
Subject	Cell Biology Cellular and Molecular Neuroscience

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