NDLI: Curcumin suppresses proliferation and invasion in human gastric cancer cells by down-regulation of PAK1 activity and cyclin D1 expression

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Curcumin suppresses proliferation and invasion in human gastric cancer cells by down-regulation of PAK1 activity and cyclin D1 expression

Content Provider	Scilit
Author	Cai, Xin-Ze Wang, Jian Xiao-Dong, Li Wang, Gui-Ling Liu, Fu-Nan Cheng, Mao-Sheng Li, Feng
Copyright Year	2009
Description	Curcumin (diferuloylmethane), is a natural chemopreventive agent known to inhibit the proliferation of several cancer cell lines. It has been previously demonstrated that curcumin is a potent inhibitor of EGF-receptor (EGFR) tyrosine kinase, but its inhibitive effect on p21-activated kinase 1 (PAK1), a downstream protein of EGFR, has not been defined. In this paper we found that curcumin repressed the expression of HER2 and inhibited the kinase activity of PAK1 without affecting its expression. Silencing HER2 in gastric cancer cells showed that even if PAK1 activity was transiently strengthened by EGF, curcumin still had a strong inhibitive effect. It should be emphasized that kinase assay in vitro showed that curcumin could act as an ATP-competitive inhibitor, which was supported by computer-aided molecular modeling. Curcumin also down-regulated the mRNA and the protein expression of cyclin D1 and suppressed transition of the cells from G1 to S phase. Therefore, curcumin inhibited the proliferation and invasion of gastric cancer cells. Overall, these results provided novel insights into the mechanisms of curcumin inhibition of gastric cancer cell growth and potential therapeutic strategies for gastric cancer.
Related Links	https://www.tandfonline.com/doi/pdf/10.4161/cbt.8.14.8720?needAccess=true
Ending Page	1368
Page Count	9
Starting Page	1360
ISSN	15384047
e-ISSN	15558576
DOI	10.4161/cbt.8.14.8720
Journal	Cancer Biology & Therapy
Issue Number	14
Volume Number	8
Language	English
Publisher	Informa UK Limited
Publisher Date	2009-07-15
Access Restriction	Open
Subject Keyword	Biochemistry and Molecular Biology Toxicology Protein Cancer Cells Gastric Cancer Inhibit the Proliferation Expression of Cyclin D1
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pharmacology Molecular Medicine Oncology

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