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Evidence for relaxation to endothelium-derived hyperpolarizing factor (EDHF) in isolated small mesenteric arteries of the mouse
| Content Provider | Scilit |
|---|---|
| Author | Vanhoutte, Paul M. |
| Copyright Year | 2003 |
| Description | At tempts to demonstrate relaxat ion mediated by endothelium-derived hyperpolar iz ing factor ( E D H F ) i n resistance arteries o f the mouse have provided apparently confl ic t ing data. In the isolated aorta, carot id , coronary and mesenteric arteries f rom C 5 7 B L 6 mice, isometric tension recording revealed clear endothelium-dependent relaxat ion to acetylcholine i n each case. These relaxations were abolished i n a l l but the mesenteric artery by the presence o f an inh ib i tor o f N O synthase. In the mesenteric artery, the addi t iona l presence o f indomethacin was required to abol ish the relaxat ion. A n identical profile o f response was recorded i n arteries taken f rom ni tr ic oxide synthase knockou t mice (Chataigneau et al, 1999). In contrast, a l though relaxat ion in mesenteric arteries f rom the same strain o f w i l d type mice was b locked by ni t roL-arg in ine plus indomethacin, i n the knock out mice the relaxations were insensitive to this combina t ion but inhibi ted i n the presence o f raised extracellular potassium (30 m M ) . A similar profile was obtained wi th isolated femoral arteries f rom these mice ( W a l d r o n et al, 1999). These latter data suggested the presence o f relaxation mediated by E D H F i n the mesenteric and femoral arteries o f the N O synthase k n o c k out mice. The only major difference between the two studies was the fact that the mesenteric arteries studied i n the latter were bo th pressurized and perfused. Book Name: Edhf 2000 |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2009-0-01726-6&isbn=9780429101700&doi=10.1201/b12802-37&format=pdf |
| Ending Page | 309 |
| Page Count | 4 |
| Starting Page | 306 |
| DOI | 10.1201/b12802-37 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2003-09-02 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Edhf 2000 Physiology Endothelium Relaxation Mesenteric Arteries Isolated |
| Content Type | Text |
| Resource Type | Chapter |
