NDLI: Proposed mechanism for the initiation of transposable element silencing by the RDR6-directed DNA methylation pathway.

Content Provider	Scilit
Author	Panda, Kaushik Slotkin, R. Keith
Copyright Year	2013
Description	The activity of transposable elements is epigenetically suppressed by both transcriptional and post-transcriptional mechanisms. We recently identified a direct connection between the small RNA-mediated post-transcriptional mRNA degradation of actively transcribing transposable elements and the de novo methylation of transposable element DNA, providing a mechanistic link between these two established pathways of transposable element silencing. Here we provide a model for the initiation, establishment and epigenetic maintenance of transposable element silencing that incorporates recent data in this rapidly emerging field.
Related Links	http://europepmc.org/articles/pmc3999056?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999056/pdf
e-ISSN	15592324
DOI	10.4161/psb.25206
Journal	Plant signaling & behavior
Issue Number	8
Volume Number	8
Language	English
Publisher	Informa UK Limited
Publisher Date	2013-08-01
Access Restriction	Open
Subject Keyword	Biochemistry and Molecular Biology Dna Methylation Rna-directed Dna Methylation Epigenetic Silencing Small Interfering Rna Transposable Element Transposon
Content Type	Text
Resource Type	Article

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