From discovery to licensure, the Adjuvant System story

Content Provider	Scilit
Author	Garçon, Nathalie Pasquale, Alberta Di
Copyright Year	2016
Description	Adjuvants are substances added to vaccines to improve their immunogenicity. Used for more than 80 years, aluminum, the first adjuvant in human vaccines, proved insufficient to develop vaccines that could protect against new challenging pathogens such as HIV and malaria. New adjuvants and new combinations of adjuvants (Adjuvant Systems) have opened the door to the delivery of improved and new vaccines against re-emerging and difficult pathogens. Adjuvant Systems concept started through serendipity. The access to new developments in technology, microbiology and immunology have been instrumental for the dicephering of what they do and how they do it. This knowledge opens the door to more rational vaccine design with implications for developing new and better vaccines.
Related Links	https://www.tandfonline.com/doi/pdf/10.1080/21645515.2016.1225635?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287309/pdf
Ending Page	33
Page Count	15
Starting Page	19
ISSN	21645515
e-ISSN	2164554X
DOI	10.1080/21645515.2016.1225635
Journal	Human vaccines & immunotherapeutics
Issue Number	1
Volume Number	13
Language	English
Publisher	Informa UK Limited
Publisher Date	2016-11-21
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Adaptive Immune Response Adjuvanted Vaccine Adjuvant Adjuvant System Innate Immune Response Vaccine Development
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Pharmacology