NDLI: Biliary tract cancers: current knowledge, clinical candidates and future challenges

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Biliary tract cancers: current knowledge, clinical candidates and future challenges

Content Provider	Scilit
Author	Tariq, Noor-Ul-Ain McNamara, Mairéad G. Valle, Juan W.
Copyright Year	2019
Description	Biliary tract cancers (BTCs) are rare with poor prognosis. Due to the advent of genomic sequencing, new data have emerged regarding the molecular makeup of this disease. To add to the complexity, various subtypes also harbor a varied genetic composition. The commonly mutated genes associated with this cancer are KRAS, EGFR, IDH, FGFR and BAP1. Various clinical studies are looking at targeting these genetic mutations. Another therapeutic area of note is the potential for the use of immunotherapy in patients with BTC. Although BTC may be a result of chronic inflammation, this does not necessarily translate into increased immunogenicity. This literature review discusses the diverse molecular and immune-related pathways in patients with BTC and their potential therapeutic implications.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446989/pdf https://www.dovepress.com/getfile.php?fileID=48816
Ending Page	2642
Page Count	20
Starting Page	2623
ISSN	11791322
DOI	10.2147/cmar.s157092
Journal	Cancer Management and Research
Volume Number	11
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-03-01
Access Restriction	Open
Subject Keyword	Gastroenterology and Hepatology Biliary Tract Cancer Extrahepatic Cholangiocarci-noma Gallbladder Cancer Genome Sequencing Immunotherapy Intrahepatic Cholangiocarcinoma Molecular Targets
Content Type	Text
Resource Type	Article
Subject	Oncology

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