NDLI: Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy

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Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy

Content Provider	Scilit
Author	Huang, Yongjia Wang, Tingting Tan, Qunyou He, Dan Wu, Mingjun Fan, Jingchuan Yang, Jie Zhong, Cailing Li, Kailing Zhang, Jingqing
Copyright Year	2021
Description	Dysfunction in the mitochondria (Mc) contributes to tumor progression. It is a major challenge to deliver therapeutic agents specifically to the Mc for precise treatment. Smart drug delivery systems are based on stimuli-responsiveness and active targeting. Here, we give a whole list of documented pathways to achieve smart stimuli-responsive (St-) and Mc-targeted DDSs (St-Mc-DDSs) by combining St and Mc targeting strategies. We present the formulations, targeting characteristics of St-Mc-DDSs and clarify their anti-cancer mechanisms as well as improvement in efficacy and safety. St-Mc-DDSs usually not only have Mc-targeting groups, molecules (lipophilic cations, peptides, and aptamers) or materials but also sense the surrounding environment and correspondingly respond to internal biostimulators such as pH, redox changes, enzyme and glucose, and/or externally applied triggers such as light, magnet, temperature and ultrasound. St-Mc-DDSs exquisitely control the action site, increase therapeutic efficacy and decrease side effects of the drug. We summarize the clinical research progress and propose suggestions for follow-up research. St-Mc-DDSs may be an innovative and sensitive precision medicine for cancer treatment.
Related Links	https://www.dovepress.com/getfile.php?fileID=70554
Ending Page	4146
Page Count	30
Starting Page	4117
e-ISSN	11782013
DOI	10.2147/ijn.s315368
Journal	International Journal of Nanomedicine
Volume Number	16
Language	English
Publisher	Informa UK Limited
Publisher Date	2021-06-01
Access Restriction	Open
Subject Keyword	Oncology Smart Delivery Stimuli-responsive Mitochondria-targeting Tumor Microenvironment Cancer Therapy
Content Type	Text
Resource Type	Article

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