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Prognostic values of baseline, interim and end-of therapy 18F-FDG PET/CT in patients with follicular lymphoma
| Content Provider | Scilit |
|---|---|
| Author | Zhou, Yeye Zhao, Zixuan Li, Jihui Zhang, Bin Sang, Shibiao Wu, Yiwei Deng, Shengming |
| Copyright Year | 2019 |
| Description | Purpose: In the present study, we aimed to investigate the role of baseline, interim and end-of treatment positron emission tomography/computed tomography (PET/CT) in assessing the prognosis of follicular lymphoma (FL). Methods: A total of 84 FL patients were retrospectively analyzed in this study. Baseline (n=59), interim (n=24, after 2–4 cycles) and end-of treatment (n=43) PET/CT images were re-evaluated, and baseline maximum standardized uptake value $(SUV_{max}$), total metabolic tumor volume (tMTV) and total lesion glycolysis (TLG) were recorded. Interim (I-PET) and end-of treatment (E-PET) PET/CT responses were interpreted by Deauville five-point scale (D-5PS) and International Harmonization Project criteria (IHP). Survival curves were calculated by Kaplan-Meier curves, and differences between groups were compared by log-rank test. Results: The 2-year progression-free survival (PFS) of the high- and low-TLG groups was 57.14% and 95.56%, respectively (p=0.0001). The 2-year overall survival (OS) of the high- and low-TLG groups was 62.50% and 100%, respectively (p0.05). However, E-PET results using D-5PS and IHP criteria were statistically significant (p=0.0001 and p=0.006). The D-5PS showed stronger prognostic value compared with IHP criteria. The optimal cutoff value of $ΔSUV_{max}$% was 66.95% according to I-PET and 68.97% according to E-PET. However, only the $ΔSUV_{max}$% from the baseline to the end-of therapy yielded statistically significant results in the prediction of PFS (p=0.0002). Conclusion: Our findings indicated that the baseline TLG and E-PET results were significantly associated with prognosis in patients with FL. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662523/pdf https://www.dovepress.com/getfile.php?fileID=51462 |
| Ending Page | 6885 |
| Page Count | 15 |
| Starting Page | 6871 |
| ISSN | 11791322 |
| DOI | 10.2147/cmar.s216445 |
| Journal | Cancer Management and Research |
| Volume Number | 11 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-07-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Follicular Lymphoma Pet/ct D-5ps |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
