NDLI: Ethylacetate extract from Tetrastigma hemsleyanum inhibits proliferation and induces apoptosis in HepG2 and SMMC-7721 cells

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Ethylacetate extract from Tetrastigma hemsleyanum inhibits proliferation and induces apoptosis in HepG2 and SMMC-7721 cells

Content Provider	Scilit
Author	Chen, Shipin Luo, Meixiu Ma, Liang Lin, Wenjun
Copyright Year	2018
Description	Ethylacetate extract from Tetrastigma hemsleyanum inhibits proliferation and induces apoptosis in HepG2 and SMMC-7721 cells Shipin Chen,1,* Meixiu Luo,1,* Liang Ma,2 Wenjun Lin1 1College of Forestry, Fujian Agriculture and Forestry University, Fuzhou City, Fujian Province 350001, China; 2Institute of Art of Landscape, Fujian Agriculture and Forestry University, Fuzhou City, Fujian Province 350001, China *These authors contributed equally to this work Purpose: This study aimed to investigate the effect of ethylacetate extract from Tetrastigma hemsleyanum (EET) on the proliferation and apoptosis of HepG2 and SMMC-7721 cells and determine the underlying mechanisms. Materials and methods: HepG2 and SMMC-7721 cells were cultured in vitro until the exponential growth phase and then treated with different concentrations of EET for 24 h. We performed a colony forming assay to determine colony forming ability, CCK8 assay to detect cell proliferation, Annexin V–FITC/PI double staining to analyze cell apoptosis, and Western blot to measure the protein expression of Caspase-3, Bcl-2, and Bax. Results: EET significantly inhibited the proliferation of HepG2 and SMMC-7721 cells in a concentration- and time-dependent manner (P
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159795/pdf https://www.dovepress.com/getfile.php?fileID=44618
Ending Page	3799
Page Count	7
Starting Page	3793
ISSN	11791322
DOI	10.2147/cmar.s168333
Journal	Cancer Management and Research
Volume Number	10
Language	English
Publisher	Informa UK Limited
Publisher Date	2018-09-01
Access Restriction	Open
Subject Keyword	Integrative and Complementary Medicine Tetrastigma Hemsleyanum Diels Et Gilg Cell Proliferation Apoptosis Hepg2 Cells Smmc-7721 Cells Caspase-3 Bcl-2
Content Type	Text
Resource Type	Article
Subject	Oncology

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Ethylacetate extract from Tetrastigma hemsleyanum inhibits proliferation and induces apoptosis in HepG2 and SMMC-7721 cells

Ethylacetate extract from Tetrastigma hemsleyanum inhibits proliferation and induces apoptosis in HepG2 and SMMC-7721 cells

Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG$_{2}$ cells

Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in $HepG_{2}$ cells

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Polysaccharides from Tetrastigma Hemsleyanum Diels et Gilg attenuate LPS-induced acute lung injury by modulating TLR4/COX-2/NF-κB signaling pathway

WWOX induces apoptosis and inhibits proliferation of human hepatoma cell line SMMC-7721

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Ethylacetate extract from Tetrastigma hemsleyanum inhibits proliferation and induces apoptosis in HepG2 and SMMC-7721 cells

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