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The Influence of Intravenous $1,25(OH)_{2}D_{3}$Therapy on Glucose Metabolism in Hemodialyzed Patients with Secondary Hyperparathyroidism
| Content Provider | Scilit |
|---|---|
| Author | Stróżecki, Paweł Kretowicz, Marek Odrowąż‐Sypniewska, Grażyna Manitius, Jacek |
| Copyright Year | 2004 |
| Description | Glucose intolerance, insulin resistance and hyperinsulinemia are common findings in end‐stage renal disease patients. Parathormone (PTH) and vitamin $D_{3}$ are linked with disturbances of glucose metabolism. Glycated hemoglobin $(HbA_{1c}$) reflects long‐term glycemic control. $HbA_{1c}$ is a marker of increased risk of death in diabetic patients but also in general population. The aim of the study was to investigate the influence of $1,25(OH)_{2}D_{3}$ therapy on long‐term control of glycemia in hemodialyzed (HD) patients with severe secondary hyperparathyroidism (SHP). Eight HD patients with SHP (PTH = 1088.6 ± 472.2) were given intravenous $1,25(OH)_{2}D_{3}$1–2 µg thrice a week, for 12 weeks (mean dose 4.5 µg/week). At baseline and after 12 weeks fasting blood was sampled for: glucose, insulin, $HbA_{1c}$, PTH. Insulin/glucose ratio (I/G) was calculated as marker of insulin resistance. Results were compared with 14 healthy volunteers (controls) matched for age, sex and BMI. At baseline I/G was higher in HD vs controls 0.110 ± 0.045 vs 0.073 ± 0.021 (p = 0.02), and of borderline significance at follow‐up (0.106 ± 0.053, p = 0.05 vs controls). PTH decreased significantly to 506.1 ± 646.3 (p < 0.02) during therapy. Significant decrease of $HbA_{1c}$ in HD patients was observed (5.84 ± 0.40 vs 5.13 ± 0.51; p = 0.01), while fasting glucose, insulin and I/G did not change significantly. Intravenous $1,25(OH)_{2}D_{3}$ therapy is successful, even in patients with severe secondary hyperparathyroidism. Significant decrease in $HbA_{1c}$ with stable insulin concentration may indicate positive impact of intravenous $1,25(OH)_{2}D_{3}$ therapy on long‐term glucose metabolism. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1081/JDI-120039815?needAccess=true |
| Ending Page | 348 |
| Page Count | 4 |
| Starting Page | 345 |
| ISSN | 0886022X |
| e-ISSN | 15256049 |
| DOI | 10.1081/jdi-120039815 |
| Journal | Renal Failure |
| Issue Number | 4 |
| Volume Number | 26 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2004-01-01 |
| Access Restriction | Open |
| Subject Keyword | Medical Laboratory Technology Insulin Resistance Intravenous Secondary Hyperparathyroidism |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine Nephrology |
