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High-Grade Anal Intraepithelial Neoplasia Among HIV-1-Infected Men Screening for a Multicenter Clinical Trial of a Human Papillomavirus Vaccine
| Content Provider | Scilit |
|---|---|
| Author | Wilkin, Timothy Lee, Jeannette Y. Lensing, Shelly Y. Stier, Elizabeth Goldstone, Stephen E. Berry, Michael J. Jay, Naomi Aboulafia, David M. Einstein, Mark H. Saah, Alfred Mitsuyasu, Ronald T. Palefsky, Joel M. |
| Copyright Year | 2013 |
| Description | Purpose: High-grade anal intraepithelial neoplasia (HGAIN) is the precursor lesion to invasive anal cancer. Human papillomavirus (HPV) vaccination holds great promise for preventing anal cancer. Methods: We examined 235 HIV-1-infected men screening for participation in a multisite clinical trial of a quadrivalent HPV vaccine. All participants had anal swabs obtained for HPV testing and cytology and high-resolution anoscopy with biopsies of visible lesions to assess for HGAIN. Results: HPV types 16 and 18 were detected in 23% and 10%, respectively; abnormal anal cytology was found in 56% and HGAIN in 30%. HGAIN prevalence was significantly higher in those with HPV16 detection compared to those without (38% vs 17%; P = .01). Use of antiretroviral therapy and nadir and current CD4+ cell count were not associated with abnormal anal cytology or HGAIN. Conclusion: HGAIN is highly prevalent in HIV-infected men. Further studies are needed on treatment and prevention of HGAIN. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676177/pdf |
| Ending Page | 79 |
| Page Count | 5 |
| Starting Page | 75 |
| ISSN | 25787489 |
| e-ISSN | 25787470 |
| DOI | 10.1310/hct1402-75 |
| Journal | HIV Research & Clinical Practice |
| Issue Number | 2 |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2013-04-01 |
| Access Restriction | Open |
| Subject Keyword | Oncology Human Papillomavirus Hiv-1 Infection Anal Intraepithelial Neoplasia Anal Infection |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Pharmacology (medical) |
