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Efficacy and safety of switching to latanoprost 0.005%–timolol maleate 0.5% fixed-combination eyedrops from an unfixed combination for 36 months
| Content Provider | Scilit |
|---|---|
| Author | Inoue, Kenji Shiokawa, Minako Tomita, Goji Fujimoto, Takayuki |
| Copyright Year | 2014 |
| Description | Efficacy and safety of switching to latanoprost 0.005%–timolol maleate 0.5% fixed-combination eyedrops from an unfixed combination for 36 months Kenji Inoue,1 Ryoko Okayama,1 Risako Higa,1 Goji Tomita2 1Inouye Eye Hospital, Tokyo, 2Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, Japan Purpose: We prospectively investigated the intraocular pressure (IOP)-reducing effect, the visual field-maintenance effect, and the adverse reactions caused by administration of latanoprost/timolol maleate fixed-combination eyedrops for 3 years. Subjects and methods: The subjects were 162 patients (162 eyes) with glaucoma or ocular hypotension who were using latanoprost and timolol maleate eyedrops concomitantly. The latanoprost and timolol maleate eyedrop regimen was discontinued without any washout period and subsequently changed to a latanoprost–timolol maleate fixed-combination eyedrop regimen. IOP values before the change and at 6, 12, 18, 24, 30, and 36 months after the change were measured and compared. The Humphrey visual field test was conducted before the change and at 12, 24, and 36 months after the change, and mean-deviation values were compared. Adverse reactions were assessed at every checkup. Results: The IOPs before the change and at 6–36 months after the change were 15.2±3.3 mmHg and 14.3–15.2 mmHg, respectively, and a significant decrease was observed at 36 months after the change (P |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086851/pdf https://www.dovepress.com/getfile.php?fileID=20698 |
| Ending Page | 1279 |
| Page Count | 5 |
| Starting Page | 1275 |
| ISSN | 11775467 |
| e-ISSN | 11775483 |
| DOI | 10.2147/opth.s63590 |
| Journal | Clinical Ophthalmology |
| Volume Number | 8 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2014-07-01 |
| Access Restriction | Open |
| Subject Keyword | Ophthalmology Intraocular Pressure Latanoprost 0.005%–timolol Maleate 0.5% Fixed Combination Safety Visual Field |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |