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Cyclin-dependent kinases as therapeutic targets for HIV-1 infection
| Content Provider | Scilit |
|---|---|
| Author | Rice, Andrew P. |
| Copyright Year | 2016 |
| Description | A number of cyclin-dependent kinases (CDKs) mediate key steps in the HIV-1 replication cycle and therefore have potential to serve as therapeutic targets for HIV-1 infection, especially in HIV-1 cure strategies. Current HIV-1 cure strategies involve the development of small molecules that are able to activate HIV-1 from latent infection, thereby allowing the immune system to recognize and clear infected cells. The role of seven CDK family members in the HIV-1 replication cycle is reviewed, with a focus on CDK9, as the mechanism whereby the viral Tat protein utilizes CDK9 to enhance viral replication is known in considerable detail. Given the essential roles of CDKs in cellular proliferation and gene expression, small molecules that inhibit CDKs are unlikely to be feasible therapeutics for HIV-1 infection. However, small molecules that activate CDK9 and other select CDKs such as CDK11 have potential to reactivate latent HIV-1 and contribute to a functional cure of infection. |
| Related Links | http://europepmc.org/articles/pmc5219930?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219930/pdf |
| Ending Page | 1461 |
| Page Count | 9 |
| Starting Page | 1453 |
| ISSN | 14600412 |
| e-ISSN | 17447631 |
| DOI | 10.1080/14728222.2016.1254619 |
| Journal | Expert opinion on therapeutic targets |
| Issue Number | 12 |
| Volume Number | 20 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-12-01 |
| Access Restriction | Open |
| Subject Keyword | Virology Latency Hiv Cure Shock and Kill Cyclin T1 P-tefb Latency Reversing Agents |
| Content Type | Text |
| Resource Type | Article |
