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Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology
| Content Provider | Scilit |
|---|---|
| Author | Husain, Zaheed Seth, Pankaj Sukhatme, Vikas |
| Copyright Year | 2013 |
| Description | Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progression. Ketogenic diets can deplete tumor-bearing animals from MDSCs and regulatory T cells, thereby improving their immunological profile. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/onci.26383?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881600/pdf |
| e-ISSN | 2162402X |
| DOI | 10.4161/onci.26383 |
| Journal | OncoImmunology |
| Issue Number | 11 |
| Volume Number | 2 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2013-11-01 |
| Access Restriction | Open |
| Subject Keyword | Immunology Research and Experimental Medicine Glycolysis Ketogenic Diet Lactate Nk Cells |
| Content Type | Text |
| Resource Type | Article |