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Long-Term Visual, Refractive and Topographic Outcomes of “Epi-off” Corneal Collagen Cross-Linking in Pediatric Keratoconus: Standard versus Accelerated Protocol
| Content Provider | Scilit |
|---|---|
| Author | Amer, Ibrahim Elaskary, Abdelhakeem Mostafa, Ali Hazem, Hazem A. Omar, Ahmed Abdou, Ahmed |
| Copyright Year | 2020 |
| Description | Purpose: To compare the visual, refractive and topographic outcomes of standard and accelerated corneal collagen cross-linking (CXL) in pediatric keratoconus patients. Methods: Prospective, comparative observational study on 68 eyes of 35 pediatric keratoconus patients (< 18 years). Patients were classified into two groups, group (I) included 34 eyes and received standard “Epi-Off” CXL (3 $mW/cm^{2}$, 30 min.) and group (II) included 34 eyes and received accelerated “Epi-Off” CXL (9 $mW/cm^{2}$, 10 min.). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent (SE), simulated keratometry (Sim K-1, Sim K-2, K-max, K-mean), cylindrical (CYL), pachymetry and Q-value were evaluated preoperatively and for 3 years postoperatively. Results: Postoperative UDVA and CDVA did not significantly change in both groups after 3 years. Postoperative SE was increased significantly in accelerated CXL (p=0.012) with no significant change in the postoperative cylinder in both procedures. Standard CXL had greater “significant” effect in decreasing Sim K-1, K-max and K-mean. The mean reduction in postoperative corneal pachymetry (at thinnest location) was significant in standard CXL (18.4 μm) (p=0.001). No significant change was noticed in postoperative Q-value. Conclusion: Standard and accelerated CXL protocols are efficient in pediatric keratoconus management with better outcomes in the standard procedure. |
| Related Links | https://www.dovepress.com/getfile.php?fileID=63343 |
| Ending Page | 3754 |
| Page Count | 8 |
| Starting Page | 3747 |
| ISSN | 11775467 |
| e-ISSN | 11775483 |
| DOI | 10.2147/opth.s275797 |
| Journal | Clinical Ophthalmology |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-11-01 |
| Access Restriction | Open |
| Subject Keyword | Ophthalmology Accelerated Cxl Corneal Collagen Cross-linking Pediatric Keratoconus Standard Cxl |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
