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Cancer-stromal interactions
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Wan Huang, Peng |
| Copyright Year | 2011 |
| Description | It has been known for a long time that the interaction between cancer cells and tissue microenvironment plays a major role in cancer development, progression and metastasis. The biochemical aspect of cancer-stromal interactions, however, is less appreciated. This short review article first provides a brief summary of the communications between cancer cells and the tissue microenvironment by direct cell-cell interactions and by soluble factors, and then describes several biochemical pathways that are important for the interaction between stromal and cancer cells with respect to energy metabolism, redox balance, cell survival and drug resistance. The potential therapeutic implications of abolishing stromal protective mechanisms to overcome drug resistance are also discussed. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.4161/cbt.11.2.14623?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230306/pdf |
| Ending Page | 156 |
| Page Count | 7 |
| Starting Page | 150 |
| ISSN | 15384047 |
| e-ISSN | 15558576 |
| DOI | 10.4161/cbt.11.2.14623 |
| Journal | Cancer Biology & Therapy |
| Issue Number | 2 |
| Volume Number | 11 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2011-01-15 |
| Access Restriction | Open |
| Subject Keyword | Pharmacology and Pharmacy Cancer-stromal Interaction Microenvironment Cancer Metabolism Drug Resistance Glycolysis Glutathione Reactive Oxygen Species |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pharmacology Molecular Medicine Oncology |
