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T-Lymphocyte Associative Recognition
| Content Provider | Scilit |
|---|---|
| Author | McCarthy, Susan A. Singer, Alfred |
| Copyright Year | 2020 |
| Description | This chapter highlights the themes—the unique focus of T-cell recognition on polymorphic major histocompatibility complex (MHC) determinants, the intrathymic development of that recognition bias, and the creation of the ligands recognized by T cells—underlie much of modern immunology. Thymus-dependent T lymphocytes play a critical role in immune responses of vertebrates to virtually all foreign antigens, including soluble as well as intrinsic cell surface antigens. Cell surface antigens eliciting T-cell responses include viral and tumor antigens on autologous cells, as well as allogeneic surface structures expressed on foreign cells. The inability of T cells to bind to isolated antigens suggests a recognition mechanism different from that of B lymphocytes. A central issue of T-cell recognition-specificity is the precise nature of the self-molecules on antigen-bearing cells required for T-cell triggering. The finding that T cells normally recognize foreign antigen only in association with polymorphic self-MHC products raises the important question of what factors control the T-cells' perception of “self.”. Book Name: Human Immunogenetics |
| Related Links | https://content.taylorfrancis.com/books/download?dac=C2006-0-08918-1&isbn=9781003065999&doi=10.1201/9781003065999-25&format=pdf |
| Ending Page | 442 |
| Page Count | 44 |
| Starting Page | 399 |
| DOI | 10.1201/9781003065999-25 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-10-22 |
| Access Restriction | Open |
| Subject Keyword | Book Name: Human Immunogenetics Physiology Lymphocytes Recognition Structures Polymorphic Surface Antigens Recognized By T Cells |
| Content Type | Text |
| Resource Type | Chapter |
