NDLI: Characterization Associated with the Frequent Severe Exacerbator Phenotype in COPD Patients

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Characterization Associated with the Frequent Severe Exacerbator Phenotype in COPD Patients

Content Provider	Scilit
Author	Wu, Yao-Kuang Su, Wen-Lin Yang, Mei-Chen Chen, Sin-Yi Wu, Chih-Wei Lan, Chou-Chin
Copyright Year	2021
Description	Background: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease with exacerbations causing hospitalizations, morbidity, and mortality. COPD exacerbation causes a substantial health impact, and its subtypes might differ in prognosis and treatment response. Methods: This study evaluated the factors of COPD exacerbations and explored the probabilities of frequent severe COPD exacerbations. Categorical and continuous variables between groups were compared. The hazard ratio (HR) and the probability of no hospital readmission were also estimated. Results: A total of 617 COPD patients were enrolled and comprised the frequent exacerbator (N = 226) and the non-frequent exacerbator (N = 391) groups. The frequent exacerbator group significantly displayed a higher eosinophil count (EC; p=0.004), a higher percentage of the frequent severe acute exacerbation history before the index hospitalization (IH; p Conclusion: Patients with EC ≥ 2%, FEV1
Related Links	https://www.dovepress.com/getfile.php?fileID=73143
Ending Page	2485
Page Count	11
Starting Page	2475
ISSN	11769106
e-ISSN	11782005
DOI	10.2147/copd.s317177
Journal	International journal of chronic obstructive pulmonary disease
Volume Number	16
Language	English
Publisher	Informa UK Limited
Publisher Date	2021-08-01
Access Restriction	Open
Subject Keyword	Respiratory System Frequent Severe Treatment Hospitalization Frequent Exacerbator Copd Exacerbations Probability
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Public Health, Environmental and Occupational Health Health Policy

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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