Loading...
Please wait, while we are loading the content...
Similar Documents
Secalonic Acid D induced leukemia cell apoptosis and cell cycle arrest of G1 with involvement of GSK-3β/β-catenin/c-Myc pathway
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Jian-Ye Tao, Li-Yang Liang, Yong-Ju Yan, Yan-Yan Dai, Chun-Ling Xia, Xue-Kui She, Zhi-Gang Lin, Yong-Cheng Fu, Li-Wu |
| Copyright Year | 2009 |
| Description | The anticancer activities of secalonic acid D separated from the secondary metabolites of the mangrove endophytic fungus No. ZSU44 were investigated in this study. Secalonic acid D showed potent cytotoxicity to HL60 and K562 cells, and the IC(50) values were 0.38 and 0.43 mumol/L, respectively. Annexin V-FITC/PI assay and western blot indicated that secalonic acid D induced apoptosis in HL60 and K562 cells. In addition, secalonic acid D led to cell cycle arrest of G(1) phase related to downregulation of c-Myc. Moreover, our data indicated that downregulation of c-Myc and cell cycle arrest of G(1) phase were caused not by formation of G-quadruplex structures but by activation of GSK-3beta followed by degradation of beta-catenin. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cc.8.15.9170?needAccess=true |
| Ending Page | 2450 |
| Page Count | 7 |
| Starting Page | 2444 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.4161/cc.8.15.9170 |
| Journal | Cell Cycle |
| Issue Number | 15 |
| Volume Number | 8 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2009-08-01 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry and Molecular Biology Apoptosis Secalonic Acid Cell Cycle Arrest Cytotoxicity Anticancer Activities |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
