NDLI: JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms

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JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms

Content Provider	Scilit
Author	Gäbler, Karoline Behrmann, Iris Haan, Claude
Copyright Year	2013
Description	The Janus kinase 2 (JAK2) mutant V617F and other JAK mutants are found in patients with myeloproliferative neoplasms and leukemias. Due to their involvement in neoplasia and inflammatory disorders, Janus kinases are promising targets for kinase inhibitor therapy. Several small-molecule compounds are evaluated in clinical trials for myelofibrosis, and ruxolitinib (INCB018424, Jakafi®) was the first Janus kinase inhibitor to receive clinical approval. In this review we provide an overview of JAK2V617F signaling and its inhibition by small-molecule kinase inhibitors. In addition, myeloproliferative neoplasms are discussed regarding the role of JAK2V617F and other mutant proteins of possible relevance. We further give an overview about treatment options with special emphasis on possible combination therapies.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772115/pdf
ISSN	21623988
e-ISSN	21623996
DOI	10.4161/jkst.25025
Journal	JAK-STAT
Issue Number	3
Volume Number	2
Language	English
Publisher	Informa UK Limited
Publisher Date	2013-07-15
Access Restriction	Open
Subject Keyword	Hematology Jak2v617f Essential Thrombocythemia Myeloproliferative Neoplasms Polycythemia Vera Primary Myelofibrosis
Content Type	Text
Resource Type	Article

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