Folic Acid Decorated Zeolitic Imidazolate Framework (ZIF-8) Loaded with Baicalin as a Nano-Drug Delivery System for Breast Cancer Therapy

Content Provider	Scilit
Author	Mi, Xiao Hu, Meigeng Dong, Mingran Yang, Zhihong Zhan, Xia Chang, Xinyue Lu, Juan Chen, Xi
Copyright Year	2021
Abstract	Background: Baicalin (BAN) has attracted widespread attention due to its low-toxicity and efficient antitumor activity, but its poor water solubility and low bioavailability severely limit its clinical application. Development of a targeted drug delivery system is a good strategy to improve the antitumor activity of baicalin. Methods: We prepared a BAN nano-drug delivery system [email protected]@BAN with a zeolite imidazole framework-8 (ZIF-8) as a carrier, which can achieve the response of folate receptor (FR). We characterized this system in terms of morphology, particle size, zeta-potential, infrared (IR), ultraviolet (UV), x-ray diffraction (XRD), and Brunel-Emmett-Teller (BET), and examined the in vitro cytotoxicity and cellular uptake properties of [email protected]@BAN using MCF-7 cells. Lastly, we established a 4T1 tumor-bearing mouse model and evaluated its in vivo anti-mammary cancer activity. Results: The [email protected]@BAN nano-delivery system had good dispersion with a BAN loading efficiency of 41.45 ± 1.43%, hydrated particle size of 176 ± 8.1 nm, Zeta-potential of − 23.83 ± 1.1 mV, and slow and massive drug release in an acidic environment (pH 5.0), whereas release was 11.03% in a neutral environment (pH 7.4). In vitro studies showed that [email protected]@BAN could significantly enhance the killing effect of BAN on MCF-7 cells, and the folic acid-mediated targeting could lead to better uptake of nanoparticles by tumor cells and thus better killing of cancer cells. In vivo studies also showed that [email protected]@BAN significantly increased the inhibition of the proliferation of solid breast cancer tumors (p < 0.01 or p < 0.001). Conclusion: The [email protected]@BAN nano-drug delivery system significantly enhanced the anti-breast cancer effect of baicalin both in vivo and in vitro, providing a more promising drug delivery system for the clinical applications and tumor management.
Related Links	https://www.dovepress.com/getfile.php?fileID=77108
Ending Page	8352
Page Count	16
Starting Page	8337
e-ISSN	11782013
DOI	10.2147/ijn.s340764
Journal	International Journal of Nanomedicine
Volume Number	16
Language	English
Publisher	Informa UK Limited
Publisher Date	2021-12-01
Access Restriction	Open
Subject Keyword	Integrative and Complementary Medicine Email Protected Folic Acid Ban Nano Drug Delivery System
Content Type	Text
Resource Type	Article