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Comparison of Two Different Intravitreal Injection Techniques
| Content Provider | Scilit |
|---|---|
| Author | Uy, Harvey S. Artiaga, Jose Carlo M. |
| Copyright Year | 2021 |
| Description | Objective: To compare the effectiveness, procedure time and safety outcomes of two different intravitreal injections (IVI) techniques. Methods: This was a prospective, single-center, randomized clinical trial of 200 adult eyes receiving intravitreal medications for various indications. Eyes were assigned (1:1) to undergo IVI using either an intravitreal injection guide (IIG) (n= 100) or conventional dual blade speculum plus surgical caliper (DBS) (n=100). All IVI were administered using a 30-gauge needle placed 4 mm posterior to the inferior limbus. The main outcome measures were rate of successful IVI administration, procedure time (seconds) as measured by a stopwatch from application to removal of IIG or DBS, patient preference for IVI technique and adverse events. Results: The two groups were similar in terms of mean age (P=0.398), laterality (P=0.671), indication for treatment (P=0.175) and medication type (P=0.489). All IVI procedures were successfully completed in both groups. The mean procedure time was shorter using the IIG (9.94 ± 2.87 seconds) versus DBS (21.85 ± 7.25 seconds) technique (P ≤ 0.01). The incidence of post-injection subconjunctival hemorrhage was higher when the DBS was applied (OR = 2.35, 95% CI = 1.22– 4.53). Patients with previous history of IVI preferred the IIG over the DBS. No other injection-related adverse events were observed in both groups. Conclusion: DBS and IIG techniques are similarly effective and safe for the administration of intravitreal medications. The IIG appears to significantly reduce procedure time, be associated with a lower incidence of subconjunctival hemorrhage and engender better patient acceptance. Clinical Trial Registration: ClinicalTrials.gov (NCT04455399). |
| Related Links | https://www.dovepress.com/getfile.php?fileID=70279 |
| Ending Page | 2389 |
| Page Count | 7 |
| Starting Page | 2383 |
| ISSN | 11775467 |
| e-ISSN | 11775483 |
| DOI | 10.2147/opth.s309501 |
| Journal | Clinical Ophthalmology |
| Volume Number | 15 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2021-06-01 |
| Access Restriction | Open |
| Subject Keyword | Ophthalmology Intravitreal Injection Intravitreal Injection Guide Anti-vascular Endothelial Growth Factor Bevacizumab Aflibercept Ranibizumab |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
