NDLI: Self-Assembling Peptide-Based Hydrogels in Angiogenesis

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Self-Assembling Peptide-Based Hydrogels in Angiogenesis

Content Provider	Scilit
Author	Han, Chaoshan Zhang, Zhiwei Sun, Jiacheng Li, Ke Li, Yangxin Ren, Chuanlu Meng, Qing You Yang, Junjie
Copyright Year	2020
Description	Abstract: Ischemic diseases, especially in the heart and the brain, have become a serious threat to human health. Growth factor and cell therapy are emerging as promising therapeutic strategies; however, their retention and sustainable functions in the injured tissue are limited. Self-assembling peptide (SAP)-based hydrogels, mimicking the extracellular matrix, are therefore introduced to encapsulate and controllably release cells, cell-derived exosomes or growth factors, thus promoting angiogenesis and tissue recovery after ischemia. We will summarize the classification, composition and structure of SAPs, and the influencing factors for SAP gelation. Moreover, we will describe the functionalized SAPs, and the combinatorial therapy of cells, exosomes or growth factors with functionalized SAPs for angiogenic process as well as its advantage in immunogenicity and injectability. Finally, an outlook on future directions and challenges is provided.
Related Links	https://www.dovepress.com/getfile.php?fileID=64840
Ending Page	10269
Page Count	13
Starting Page	10257
e-ISSN	11782013
DOI	10.2147/ijn.s277046
Journal	International Journal of Nanomedicine
Volume Number	15
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-12-01
Access Restriction	Open
Subject Keyword	Angiogenesis Hydrogel Retention Self‐assembling Peptide Survival
Content Type	Text
Resource Type	Article

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