NDLI: Genetic deletion of microglial Panx1 attenuates morphine withdrawal, but not analgesic tolerance or hyperalgesia in mice

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Genetic deletion of microglial Panx1 attenuates morphine withdrawal, but not analgesic tolerance or hyperalgesia in mice

Content Provider	Scilit
Author	Burma, Nicole E. Leduc-Pessah, Heather Trang, Tuan
Copyright Year	2017
Description	Opioids are among the most powerful analgesics for managing pain, yet their repeated use can lead to the development of severe adverse effects. In a recent study, we identified the microglial pannexin-1 channel (Panx1) as a critical substrate for opioid withdrawal. Here, we investigated whether microglial Panx1 contributes to opioid-induced hyperalgesia (OIH) and opioid analgesic tolerance using mice with a tamoxifen-inducible deletion of microglial Panx1. We determined that escalating doses of morphine resulted in thermal pain hypersensitivity in both Panx1-expressing and microglial Panx1-deficient mice. In microglial Panx1-deficient mice, we also found that acute morphine antinociception remained intact, and repeated morphine treatment at a constant dose resulted in a progressive decline in morphine antinociception and a reduction in morphine potency. This reduction in morphine antinociceptive potency was indistinguishable from that observed in Panx1-expressing mice. Notably, morphine tolerant animals displayed increased spinal microglial reactivity, but no change of microglial Panx1 expression. Collectively, our findings indicate microglial Panx1 differentially contributes to opioid withdrawal, but not the development of opioid-induced hyperalgesia or tolerance.
Related Links	https://www.tandfonline.com/doi/pdf/10.1080/19336950.2017.1359361?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626365/pdf
Ending Page	494
Page Count	8
Starting Page	487
ISSN	19336950
e-ISSN	19336969
DOI	10.1080/19336950.2017.1359361
Journal	Channels
Issue Number	5
Volume Number	11
Language	English
Publisher	Informa UK Limited
Publisher Date	2017-08-18
Access Restriction	Open
Subject Keyword	Research and Experimental Medicine Microglia Opioid Analgesic Tolerance Opioid-induced Hyperalgesia Opioid Withdrawal Pannexin-1
Content Type	Text
Subject	Medicine Biochemistry Biophysics

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