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Effect of Acidosis on Heart Camp-Dependent Protein Kinase
| Content Provider | Scilit |
|---|---|
| Author | Mon, Liliana E. Chiappe De Cingolani, Gladys E. Chiappe De Cingolani, H. E. |
| Copyright Year | 1978 |
| Description | The effect of acidosis on cAMP-dependent protein kinase activity in perfused hearts from normal and reserpinized rats has been investigated. The results were compared to the effect of acidosis on myocardial contractility under the same conditions. The results showed that acidosis increases the cAMP-dependent protein kinase activity in normal hearts. This increase was abolished when the hearts were depleted of norepinephrine by previous treatment with reserpine. As regards myocardial contractility, there was a similar decrease by acidosis either in normal hearts with increased cAMP-dependent protein kinase activity or in reserpinized hearts in which the increase in protein kinase activity was prevented. Two alternative hypotheses are suggested : (1) a dissociation between contractility and cAMP levels, or (2) a “blockade” by acidosis of the mechanical effect of increasing cAMP-dependent protein kinase activity. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/13813457809069905 |
| Ending Page | 287 |
| Page Count | 11 |
| Starting Page | 277 |
| ISSN | 00039799 |
| DOI | 10.3109/13813457809069905 |
| Journal | Archives internationales de physiologie et de biochimie |
| Issue Number | 2 |
| Volume Number | 86 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1978-01-01 |
| Access Restriction | Open |
| Subject Keyword | Peripheral Vascular Disease Camp Dependent Protein Kinase |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Biochemistry |
